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Novel Gene Sets Identified that Regulate the Survival of Leukemia Stem Cells

Leukemia stem cells (LSCs) represent a biologically distinct subpopulation of myeloid leukemias, with reduced cell cycle activity and increased resistance to therapeutic challenge. Elucidating the...

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Identification of a Key Regulatory Factor in Hematopoiesis and Cancer

 A new paper in Cancer Cell from Ulrich Steidl, M.D., Ph.D., and colleagues at the Albert Einstein College of Medicine, identifies a key transcription factor that regulates hematopoiesis and has a role...

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Molecular Mechanisms of Reprogramming Unveiled

The ability to reprogram cells from a differentiated to an embryonic stem cell-like fate, producing induced pluripotent stem cells, or iPSCs, has revolutionized biology.  Although the process appears...

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Gene Therapy for α-Thalassemia in iPS Cells

Alpha-thalassemia, a form of blood diseases caused by deletions in the α-globin gene cluster, is a candidate for stem cell based gene therapy combined with cell replacement therapy.  This is because...

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Amniotic Fluid Cells Reprogrammed to Endothelial Cells

A new report in Cell from Shahin Rafii, M.D. and colleagues at Weill Cornell Medical College demonstrates direct reprogramming of human amniotic fluid-derived cells into functional vascular endothelial...

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The Ubiquitin-Proteasome System Adds Complexity to Pluripotency and...

 Postranslational modification, the adding of chemical moieties to proteins after they are translated from RNA, is a common and complex method of regulating the function and abundance of proteins....

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Two NYSTEM-funded Scientists Elected as Fellows to AAAS

Two NYSTEM-funded scientists, Dr. Shahin Rafii, M.D., from Weill Cornell Medical College, and Dr. Ming-Ming Zhou, Ph.D, from the Mount Sinai School of Medicine, were elected as Fellows of the American...

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Patient Cells Yield Potential Therapies For Familial Dysautonomia

 Induced pluripotent stem cells (iPSCs) from disease-afflicted patients have been touted for their ability to yield ‘disease-in-a-dish’ models for drug screening.  Now a team led by Lorenz Studer,...

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Novel Scientific Technique to Help Prevent Inherited Mitochondrial Diseases

Mitochondria are the power plants of cells. Diseases caused by mutations in mitochondrial DNA can have significant impact on cellular function and lead to muscle weakness, heart disease, diabetes,...

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NYSTEM Funded Scientist Receives Audacious Idea Prize From National Eye...

Dr. Jeffrey Stern, M.D., Ph.D., a practicing physician and a researcher at the Neural Stem Cell Institute in Rensselaer, NY, received one of only ten prizes under the National Eye Institutes' Audacious...

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A New Cell-Based Therapy to Treat Leukemia

Drs. Michel Sadelain, M.D., Ph.D., Renier Brentjens, M.D., Ph.D., and Isabelle Rivière, Ph.D.,  plus a team of researchers based at Memorial Sloan-Kettering Cancer Center, developed a new treatment for...

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A New Source of Cancer in the Ovary

Combining efforts, a team led by Alex Nikitin, M.D., Ph.D., of Cornell University, in collaboration with the lab of Grigori Enikolopov, Ph.D., of Cold Spring Harbor Laboratory, identified a new stem...

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NANOG Recruitment of TET Aids Reprogramming

 Removal of DNA methylation is important for resetting chromatin to a pluripotent state.  Jianlong Wang, Ph.D., at the Icahn School of Medicine at Mount Sinai, and colleagues recently published a...

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Glioma Progenitor Cells Have a Unique Gene Expression Profile

Gliomas account for over 80% of malignant brain tumors and current treatments have limited effect on patient outcome.  Now, a new paper in Cell Reports from the lab of Dr. Steven Goldman, M.D., Ph.D.,...

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Stimulation of Endogenous Neural Progenitor Cells Slows the Progression of...

Huntington’s disease (HD) is a neurodegenerative disorder characterized by the progressive loss of striatal medium spiny projection neurons (MSNs). Abdellatif Benraiss, PhD, and Steven A. Goldman, MD,...

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Nail Stem Cells Coordinate Nail Growth and Digit Regrowth

A new paper published in Nature describes the role of nail stem cells in coordinating both nail growth and regrowth of digit-tips after amputation in mice.  Researchers in the lab of Dr. Mayumi Ito,...

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Endothelial Cells Show Tissue-Specificity

Endothelial cells (ECs) form the lining of blood and lymphatic vessels throughout the body.  While tissue-specific ECs have long been recognized for a subset of tissues, Dr. Shahin Rafii’s lab at Weill...

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Michel Sadelain recognized for Thalassemia work

Dr. Michel Sadelain, M.D., Ph.D., at Memorial Sloan-Kettering Cancer Center, has been working for two decades on a gene-therapy based cure using stem cells for the blood disease β-thalassemia. Last...

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Signals Controlling Liver Regeneration Revealed

 The human liver has an impressive ability to regenerate in response to acute injury. However, in the case of chronic injury, liver damage leads to fibrosis, or scarring, rather than regeneration....

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Mechanism of Fragile X Syndrome Revealed

Fragile X syndrome (FXS) is caused by expansion of the CGG trinucleotide repeat in the Fragile X Mental Retardation gene, FMR1. FXS results in intellectual disability along with other physical and...

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